Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 13/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 16/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10089029 | 0.91 | S1PR5 (0.63) | S1PR5S1PR1GRK5CDK8S1PR3 | |
| SCHEMBL10089068 | 0.89 | S1PR5 (0.48) | S1PR5HTR2CMCHR1S1PR1S1PR3 | |
| SCHEMBL10310549 | 0.87 | S1PR1 (0.41) | S1PR5HTR2CMCHR1S1PR1GRK5 | |
| SCHEMBL10089037 | 0.86 | S1PR1 (0.56) | S1PR5HTR2CMCHR1S1PR1S1PR3 | |
| SCHEMBL10088988 | 0.86 | S1PR5 (0.44) | S1PR5HTR2CMCHR1S1PR1GRK5 | |
| SCHEMBL10089024 | 0.85 | S1PR5 (0.48) | S1PR5S1PR1GRK5CDK8S1PR3 | |
| SCHEMBL10088950 | 0.84 | S1PR5 (0.55) | S1PR5S1PR1S1PR3S1PR4PDGFRA | |
| SCHEMBL10089043 | 0.84 | MAPK1 (0.50) | S1PR5HTR2CMCHR1S1PR1 | |
| SCHEMBL10088994 | 0.84 | S1PR1 (0.42) | S1PR5HTR2CMCHR1S1PR1S1PR3 | |
| SCHEMBL10089078 | 0.83 | S1PR1 (0.47) | S1PR5HTR2CMCHR1S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193378-B2 | 2H-chromene compound and derivative thereof | ASTELLAS PHARMA INC. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230463-A1 | 2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF | S1PR1, S1PR2, CCR1 | S1PR5 4/4885HTR2C 322/4885MCHR1 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.