Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 12/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9957504 | 0.81 | PIK3C3 (0.74) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957490 | 0.75 | KDM4E (0.51) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL10089589 | 0.71 | PIK3C3 (0.55) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957233 | 0.70 | CDK2 (0.50) | CDK2CDK4GSK3BCCNKCCNC | |
| SCHEMBL9956682 | 0.68 | PIK3C3 (0.79) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL9957829 | 0.67 | PIK3C3 (0.73) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL15765721 | 0.67 | PIK3C3 (0.73) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390643 | 0.67 | PIK3C3 (0.80) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390620 | 0.67 | PIK3C3 (0.76) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB | |
| SCHEMBL16390921 | 0.66 | PIK3C3 (1.00) | PIK3C3PIK3CDPIK3CAPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085815-A1 | BI-HETEROARYL COMPOUNDS AS VPS34 INHIBITORS | NOVARTIS AG (CH) | 2012-06-28 | — | — | WO | disclosed |