Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 7/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091011 | 0.95 | CNR2 (0.40) | CNR2KCNK3HDAC4HDAC6IDH1 | |
| SCHEMBL10090997 | 0.93 | CNR2 (0.43) | CNR2GRM2 | |
| SCHEMBL10091050 | 0.87 | TP53 (0.43) | — | |
| SCHEMBL10090971 | 0.87 | TP53 (0.44) | — | |
| SCHEMBL4117922 | 0.86 | CNR2 (0.36) | CNR2HDAC4HDAC6IDH1RIPK1 | |
| SCHEMBL4117926 | 0.86 | CNR2 (0.36) | CNR2HDAC4HDAC6IDH1RIPK1 | |
| SCHEMBL4116076 | 0.85 | CNR2 (0.51) | CNR2HDAC4HDAC6IDH1RIPK1 | |
| SCHEMBL4116070 | 0.85 | CNR2 (0.51) | CNR2HDAC4HDAC6IDH1RIPK1 | |
| SCHEMBL10091029 | 0.84 | CNR2 (0.37) | CNR2HDAC4HDAC6IDH1RIPK1 | |
| SCHEMBL10091094 | 0.83 | CNR2 (0.36) | CNR2GRM2IDH1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835422-B2 | Substituted imidazoheterocycle derivatives | CARA THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835422-B2 | Substituted imidazoheterocycle derivatives | CARA THERAPEUTICS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120015930-A1 | SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES | CARA THERAPEUTICS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20120015930-A1 | SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES | CARA THERAPEUTICS, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015930-A1 | SUBSTITUTED IMIDAZOHETEROCYCLE DERIVATIVES | CNR1, CNR2, HRH1 | CNR2 2/4885KCNK3 1442/4885GRM2 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.