Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094264 | 0.81 | CYP1A2 (0.52) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL884935 | 0.74 | KCNA5 (0.59) | CYP1A2CYP2C9PIK3CA | |
| SCHEMBL10094221 | 0.72 | MAPK1 (0.46) | CYP1A2CYP2C9PIK3CALRRK2MAPK1 | |
| SCHEMBL21024668 | 0.71 | CYP1A2 (0.48) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL13018542 | 0.70 | CYP1A2 (0.52) | CYP1A2CYP2C9PIK3CAPIK3CDPIK3CG | |
| SCHEMBL24809669 | 0.70 | IRAK4 (0.43) | CYP1A2CYP2C9 | |
| SCHEMBL13322391 | 0.68 | LRRK2 (0.46) | CYP1A2CYP2C9LRRK2MAPK1SOS1 | |
| SCHEMBL3436634 | 0.68 | CYP1A2 (0.56) | CYP1A2CYP2C9PIK3CALRRK2MAPK1 | |
| SCHEMBL26790144 | 0.68 | CYP1A2 (0.45) | CYP1A2CYP2C9 | |
| SCHEMBL10094245 | 0.68 | CYP1A2 (0.49) | CYP1A2CYP2C9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | CYP1A2 2371/4885CYP2C9 2201/4885PIK3CA 2005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.