Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13280984 | 0.93 | GRM5 (0.51) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL13280600 | 0.85 | GRM5 (0.51) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL1010518 | 0.83 | GRM5 (0.60) | GRM5ALDH1A1HPGDPOLBTDP1 | |
| SCHEMBL13281274 | 0.82 | GRM5 (0.62) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL1008934 | 0.80 | GRM5 (0.49) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL13281219 | 0.79 | GRM5 (0.53) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL1009560 | 0.79 | GRM5 (0.53) | GRM5ALDH1A1HPGDESR2POLB | |
| SCHEMBL2162762 | 0.78 | GRM5 (0.52) | GRM5ALDH1A1HPGDKDM4EESR2 | |
| SCHEMBL1009869 | 0.76 | GRM5 (0.50) | GRM5ALDH1A1HPGDESR2POLB | |
| SCHEMBL1010202 | 0.75 | GRM5 (0.49) | GRM5ALDH1A1ESR2POLBESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO KGAA (DE) | 2011-01-05 | — | — | EP | claimed |