Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.52 |
| ▸ | JAK1 | P23458 | 10/20 | 0.51 |
| ▸ | JAK3 | P52333 | 9/20 | 0.51 |
| ▸ | JAK2 | O60674 | 8/20 | 0.51 |
| ▸ | TYK2 | P29597 | 8/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099170 | 0.97 | PDE4B (0.55) | PDE4BJAK1JAK3JAK2TYK2 | |
| SCHEMBL14697191 | 0.88 | JAK1 (0.51) | PDE4BJAK1JAK3JAK2TYK2 | |
| SCHEMBL14708561 | 0.88 | JAK3 (0.57) | PDE4BJAK1JAK3JAK2TYK2 | |
| SCHEMBL1933112 | 0.87 | PDE4B (0.58) | PDE4BJAK1JAK3ADORA1 | |
| SCHEMBL10099188 | 0.85 | JAK2 (0.45) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL10099180 | 0.85 | JAK2 (0.45) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL10099181 | 0.82 | JAK1 (0.42) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL10099187 | 0.82 | JAK1 (0.42) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL10099136 | 0.82 | JAK2 (0.42) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL20955984 | 0.82 | JAK1 (0.44) | PDE4BJAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120034250-A1 | CONDENSED PYRROLOPYRIDINE DERIVATIVE | JAK2, JAK1, JAK3 | PDE4B 2241/4885JAK1 2/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.