Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.58 |
| ▸ | ACP1 | P24666 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10099707 | 0.87 | PDE10A (0.58) | PDE10AACP1 | |
| SCHEMBL24956782 | 0.81 | PDE10A (0.52) | PDE10AACP1LMNACYP1A2CYP3A4 | |
| SCHEMBL1829467 | 0.74 | PDE10A (1.00) | PDE10A | |
| SCHEMBL259023 | 0.74 | PDE10A (0.51) | PDE10ALMNAALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL10099712 | 0.73 | CNR1 (0.49) | PDE10ACNR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL259710 | 0.73 | PDE10A (1.00) | PDE10A | |
| SCHEMBL259692 | 0.73 | PDE10A (1.00) | PDE10A | |
| SCHEMBL1825901 | 0.73 | PDE10A (1.00) | PDE10A | |
| SCHEMBL17401013 | 0.72 | PDE10A (0.44) | PDE10AACP1 | |
| SCHEMBL259076 | 0.70 | PDE10A (0.52) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007006-A1 | TRIAZOLO- AND PYRAZOLOQUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITOR | H. LUNDBECK A/S (DK) | 2012-01-19 | — | — | WO | disclosed |