Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101131 | 0.84 | PIK3CB (0.47) | PIK3CBENTPD5TRPV1IDO1CYP19A1 | |
| SCHEMBL10101121 | 0.83 | TRPV1 (0.49) | PIK3CBENTPD5CETPTRPV1IDO1 | |
| SCHEMBL387738 | 0.83 | PIK3CB (0.36) | PIK3CBENTPD5CETPCYP3A4ALDH1A1 | |
| SCHEMBL10101134 | 0.80 | PIK3CB (0.43) | PIK3CBENTPD5CETPTRPV1IDO1 | |
| SCHEMBL10101208 | 0.80 | PIK3CB (0.43) | PIK3CBENTPD5CETPTRPV1IDO1 | |
| SCHEMBL10101140 | 0.78 | PIK3CB (0.43) | PIK3CBENTPD5TRPV1IDO1CYP19A1 | |
| SCHEMBL386764 | 0.77 | ENTPD5 (0.51) | PIK3CBENTPD5CETPTRPV1CYP3A4 | |
| SCHEMBL10101130 | 0.75 | PIK3CB (0.41) | PIK3CBENTPD5CETPTRPV1CYP19A1 | |
| SCHEMBL10101314 | 0.75 | TRPV1 (0.40) | PIK3CBENTPD5TRPV1IDO1CYP19A1 | |
| SCHEMBL10101162 | 0.75 | PIK3CB (0.43) | PIK3CBENTPD5TRPV1IDO1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101605-B2 | SHIP1 modulators and methods related thereto | AQUINOX PHARMACEUTICALS INC. (CA) | 2012-01-24 | — | — | US | disclosed |
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | AQUINOX PHARMACEUTICALS INC. (CA) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136802-A1 | SHIP1 MODULATORS AND METHODS RELATED THERETO | PPM1D, PTPRO, PPM1G | PIK3CB 98/4885ENTPD5 750/4885CETP 2346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.