Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 14/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | GAK | O14976 | 2/20 | 0.57 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119049 | 0.82 | RIPK2 (0.57) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL23999580 | 0.82 | CA9 (0.54) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL600081 | 0.81 | RIPK2 (0.58) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL600768 | 0.80 | RIPK2 (0.60) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL601819 | 0.78 | RIPK2 (1.00) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL17059454 | 0.78 | RIPK2 (0.54) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL18670892 | 0.78 | RIPK2 (0.50) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| Water SCHEMBL601248 | 0.78 | RIPK2 (0.98) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL18670894 | 0.77 | RIPK2 (0.47) | RIPK2KCNH2MAPK14GAKRIPK3 | |
| SCHEMBL18670901 | 0.77 | RIPK2 (0.47) | RIPK2KCNH2MAPK14GAKRIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | ABL1, MAP3K20, MAP3K19 | RIPK2 480/4885KCNH2 824/4885MAPK14 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.