Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 20/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 20/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 20/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 19/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 19/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 19/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012579 | 0.89 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL8252196 | 0.88 | HDAC3 (1.00) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1011844 | 0.88 | HDAC3 (0.78) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1012457 | 0.87 | HDAC3 (0.80) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1012170 | 0.86 | HDAC3 (0.78) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1011731 | 0.86 | HDAC3 (0.80) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1011818 | 0.85 | HDAC3 (0.77) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| Hydrochloric Acid SCHEMBL1012524 | 0.85 | HDAC3 (0.77) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1012598 | 0.84 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL1011116 | 0.83 | HDAC3 (0.79) | HDAC3HDAC1HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881977-B1 | HISTONE DEACETYLASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-01-05 | — | — | EP | disclosed |