Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 18/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 12/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.57 |
| ▸ | PRKACA | P17612 | 3/20 | 0.56 |
| ▸ | PRKACG | P22612 | 3/20 | 0.56 |
| ▸ | PRKACB | P22694 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10107430 | 0.84 | LIMK2 (0.56) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL4301992 | 0.82 | LIMK2 (0.84) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL10107383 | 0.79 | LIMK2 (0.52) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL13951179 | 0.78 | LIMK2 (0.70) | LIMK2LIMK1ROCK1ROCK2 | |
| SCHEMBL1446861 | 0.76 | LIMK2 (0.47) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL4297068 | 0.74 | LIMK2 (0.81) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL1446658 | 0.74 | LIMK2 (0.46) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL28784029 | 0.73 | LIMK2 (0.80) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL27782496 | 0.73 | LIMK2 (0.86) | LIMK2LIMK1ROCK1ROCK2PRKACA | |
| SCHEMBL2715524 | 0.73 | LIMK2 (0.76) | LIMK2LIMK1ROCK1ROCK2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193202-B2 | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090264450-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264450-A1 | LIMK2 INHIBITORS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE | LIMK2, LIMK1, LIMA1 | LIMK2 1/4885LIMK1 2/4885ROCK1 308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.