Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
| ▸ | GAB1 | Q13480 | 1/20 | 0.55 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891686 | 0.81 | AKT1 (0.65) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108268 | 0.80 | AKT1 (0.69) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108706 | 0.80 | AKT1 (0.69) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108716 | 0.80 | AKT1 (0.69) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108715 | 0.80 | AKT1 (0.69) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL11893079 | 0.80 | AKT1 (0.69) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108482 | 0.79 | AKT1 (0.59) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL328445 | 0.74 | AKT1 (0.68) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL10108714 | 0.73 | AKT1 (0.67) | AKT1PDPK1ABCB11AKT2GAB1 | |
| SCHEMBL11891721 | 0.73 | AKT1 (0.52) | AKT1TSHRMEN1KMT2ACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-A1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | The Board of Regents of the University of Texas System (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2009129267-A2 | SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-10-22 | — | — | WO | disclosed |