Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.72 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.72 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.72 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922582 | 1.00 | PTGDR2 (0.72) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| Bi-671800 SCHEMBL2788886 | 0.84 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| Bi-671800 SCHEMBL12415807 | 0.84 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| Bi-671800 SCHEMBL12415799 | 0.84 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| Bi-671800 SCHEMBL525024 | 0.84 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| Bi-671800 SCHEMBL12415720 | 0.84 | PTGDR2 (1.00) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| SCHEMBL12556772 | 0.83 | PTGDR2 (0.80) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| SCHEMBL1011000 | 0.82 | PTGDR2 (0.84) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| SCHEMBL525025 | 0.81 | TBXA2R (0.71) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 | |
| SCHEMBL12556770 | 0.81 | PTGDR2 (0.89) | PTGDR2TBXA2RPTGDRCTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960393-B2 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 | ACTIMIS PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1633726-B1 | PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES MEDIATED BY CRTH2 | ACTIMIS PHARMACEUTICALS INC (US) | 2011-01-05 | — | — | EP | disclosed |