Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 9/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 9/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203125 | 0.88 | ACACB (0.50) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL12723461 | 0.85 | ACACB (0.50) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL12760571 | 0.84 | ACACB (0.52) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL8244150 | 0.84 | ACACB (0.53) | ACACBOGAPOLBMAPTLMNA | |
| Hydrochloric Acid SCHEMBL1011914 | 0.83 | ACACB (0.52) | ACACBOGAPOLBMAPTLMNA | |
| SCHEMBL8205621 | 0.82 | ACACB (0.49) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL649475 | 0.80 | OGA (0.47) | ACACBOGAHDAC1HDAC6POLB | |
| SCHEMBL12723454 | 0.79 | ACACB (0.53) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL12723479 | 0.79 | ACACB (0.51) | ACACBOGAHDAC3HDAC4HDAC1 | |
| SCHEMBL1010636 | 0.79 | ACACB (0.45) | ACACBOGAHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476289-B2 | Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace | JANSSEN PHARMACEUTICA NV (BE) | 2013-07-02 | — | — | US | disclosed |
| EP-2274301-B1 | AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-09-26 | — | — | EP | disclosed |
| US-7932246-B2 | Histone deacetylase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-04-26 | — | — | US | disclosed |
| US-7932246-B2 | Histone deacetylase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-04-26 | — | — | US | disclosed |
| US-7932246-B2 | Histone deacetylase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-04-26 | — | — | US | disclosed |
| US-20110015218-A1 | AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-20 | — | — | US | disclosed |
| EP-2274301-A1 | AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | Janssen Pharmaceutica, N.V. (BE) | 2011-01-19 | — | — | EP | disclosed |
| EP-1881977-B1 | HISTONE DEACETYLASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-01-05 | — | — | EP | disclosed |
| EP-1881977-B1 | HISTONE DEACETYLASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-01-05 | — | — | EP | disclosed |
| US-20100152155-A1 | Histone Deacetylase Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2010-06-17 | — | — | US | disclosed |
| US-20100152155-A1 | Histone Deacetylase Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2010-06-17 | — | — | US | disclosed |
| US-20100152155-A1 | Histone Deacetylase Inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2010-06-17 | — | — | US | disclosed |
| WO-2009118370-A1 | AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-01 | — | — | WO | disclosed |
| EP-1881977-A1 | HISTONE DEACETYLASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006123121-A1 | HISTONE DEACETYLASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-23 | — | — | WO | disclosed |
| WO-2006123121-A1 | HISTONE DEACETYLASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015218-A1 | AZA-BICYCLOHEXYL SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC2 | ACACB 642/4885OGA 1472/4885HDAC3 5/4885 |
| US-20100152155-A1 | Histone Deacetylase Inhibitors | HDAC1, HDAC2, HDAC11 | ACACB 1153/4885OGA 1579/4885HDAC3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.