Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CASR | P41180 | 9/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932049 | 0.85 | CASR (0.61) | SMN1; SMN2MEN1KMT2ACASRLMNA | |
| SCHEMBL10109804 | 0.85 | CASR (0.62) | MEN1KMT2ACASRHTTLMNA | |
| SCHEMBL10109710 | 0.82 | CASR (0.48) | CASRHTTHTR1AADORA3CHRM1 | |
| SCHEMBL14469578 | 0.74 | SMN1; SMN2 (0.82) | SMN1; SMN2MEN1KMT2ACASRHTT | |
| SCHEMBL13868585 | 0.74 | CASR (0.62) | SMN1; SMN2MEN1KMT2ACASRLMNA | |
| SCHEMBL541312 | 0.73 | NPC1 (0.53) | SMN1; SMN2MEN1KMT2ACASRHTT | |
| SCHEMBL541313 | 0.73 | NPC1 (0.53) | SMN1; SMN2MEN1KMT2ACASRHTT | |
| SCHEMBL1750017 | 0.72 | SMN1; SMN2 (0.72) | SMN1; SMN2MEN1KMT2ACASRHDAC1 | |
| SCHEMBL4705737 | 0.72 | SMN1; SMN2 (0.72) | SMN1; SMN2MEN1KMT2ACASRHDAC1 | |
| SCHEMBL3678776 | 0.71 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2ACASRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509518-B1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176322-B2 | Calcium receptor modulating agents | AMGEN INC. (US) | 2007-02-13 | — | — | US | disclosed |