Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 18/20 | 0.43 |
| ▸ | KDR | P35968 | 18/20 | 0.43 |
| ▸ | KIT | P10721 | 17/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL689617 | 0.84 | PDGFRB (0.54) | PDGFRBKDRKITRETFLT1 | |
| SCHEMBL687485 | 0.81 | KDR (0.61) | PDGFRBKDRKITRETFLT1 | |
| SCHEMBL689166 | 0.81 | KDR (0.56) | PDGFRBKDRKITRETFLT1 | |
| SCHEMBL689986 | 0.79 | KDR (0.59) | PDGFRBKDRKITRETFLT1 | |
| SCHEMBL689469 | 0.79 | PDGFRB (0.50) | PDGFRBKDRKITRETFLT1 | |
| SCHEMBL689002 | 0.79 | PDGFRB (0.58) | PDGFRBKDRKITKDM4E | |
| SCHEMBL688015 | 0.77 | PDGFRB (0.59) | PDGFRBKDRKITKDM4E | |
| SCHEMBL687487 | 0.76 | PDGFRB (0.59) | PDGFRBKDRKITKDM4EPOLB | |
| SCHEMBL689099 | 0.75 | PDGFRB (0.55) | PDGFRBKDRKITKDM4E | |
| SCHEMBL689038 | 0.75 | PDGFRB (0.60) | PDGFRBKDRKITRETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2123649-B1 | 3-PYRROLO-CYCLOHEXYLENE-2-DIHYDRO-INDOLINONE DERIVATIVES AND USES THEREOF | JIANGSU SIMCERE PHARMACEUTICAL R & D CO LTD (CN) | 2012-02-29 | — | — | EP | disclosed |