Sugi Predict

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SCHEMBL10114197

SCHEMBL10114197

Cc1cccc(SCCNC(=O)C2CCC(NS(=O)(=O)C(C)(C)C)CC2)c1C

nearest known ligand 0.43

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ GFER P55789 1/20 0.43
▸ NPY5R Q15761 1/20 0.42
▸ TP53 P04637 2/20 0.38
▸ MAPT P10636 3/20 0.36
▸ RAB9A P51151 2/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ NPC1 O15118 1/20 0.35
▸ HTR7 P34969 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ EPHX2 P34913 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13565739 0.84 NPC1 (0.33) NPY5RMAPTRAB9ASMN1; SMN2NPC1
SCHEMBL10114182 0.78 NPY5R (0.43) GFERNPY5RMAPTRAB9ASMN1; SMN2
SCHEMBL10114192 0.77 NPY5R (0.41) GFERNPY5RMAPTRAB9ASMN1; SMN2
SCHEMBL13203780 0.76 RECQL (0.48) NPY5RTP53MAPTSMN1; SMN2LMNA
SCHEMBL10133357 0.76 RECQL (0.48) NPY5RTP53MAPTSMN1; SMN2LMNA
SCHEMBL10113301 0.76 MAPT (0.60) NPY5RTP53MAPTSMN1; SMN2NPC1
SCHEMBL13203837 0.76 MAPT (0.60) NPY5RTP53MAPTSMN1; SMN2NPC1
SCHEMBL10114144 0.75 CA12 (0.52) NPY5RTP53MAPTLMNAKMT2A
SCHEMBL13203787 0.74 MAPT (0.57) GFERNPY5RTP53MAPT
SCHEMBL10133713 0.74 MAPT (0.57) GFERNPY5RTP53MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-8115027-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2012-02-14 — — US disclosed
US-20110039802-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2011-02-17 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-20100292500-A1 NPY Y5 ANTAGONIST KAWANISHI YASUYUKI 2010-11-18 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7781461-B2 NPY Y5 antagonist KAWANISHI YASUYUKI 2010-08-24 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-7265130-B2 NPY Y5 antagonist SHIONOGI & CO., LTD. (JP) 2007-09-04 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed
US-20070015762-A1 NPY Y5 antagonist KAWANISHI YASUYUKI 2007-01-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070015762-A1 NPY Y5 antagonist NPY5R, NPY1R, NPY2R GFER 1450/4885NPY5R 1/4885TP53 4449/4885
US-20100292500-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R GFER 1505/4885NPY5R 1/4885TP53 4417/4885
US-20110039802-A1 NPY Y5 ANTAGONIST NPY5R, NPY1R, NPY2R GFER 1466/4885NPY5R 1/4885TP53 4486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.