Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MALT1 | Q9UDY8 | 11/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13204311 | 1.00 | SMN1; SMN2 (0.62) | SMN1; SMN2MALT1TSHRALDH1A1HPGD | |
| SCHEMBL13204304 | 0.90 | POLB (0.58) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL10114754 | 0.90 | POLB (0.58) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL13204303 | 0.88 | KMT2A (0.59) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10114777 | 0.88 | KMT2A (0.59) | SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL13204309 | 0.87 | POLB (0.49) | SMN1; SMN2MALT1ALDH1A1HPGDACLY | |
| SCHEMBL10114755 | 0.87 | POLB (0.49) | SMN1; SMN2MALT1ALDH1A1HPGDACLY | |
| SCHEMBL10114368 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2MALT1TSHRALDH1A1HPGD | |
| SCHEMBL10133753 | 0.85 | SMN1; SMN2 (0.62) | SMN1; SMN2MALT1TSHRALDH1A1HPGD | |
| SCHEMBL10115905 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MALT1TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7781461-B2 | NPY Y5 antagonist | KAWANISHI YASUYUKI | 2010-08-24 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | SMN1; SMN2 2197/4885MALT1 3148/4885TSHR 189/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | SMN1; SMN2 2251/4885MALT1 3409/4885TSHR 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.