Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10086505 | 0.87 | NPC1 (0.47) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10086521 | 0.85 | NPC1 (0.48) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10085746 | 0.85 | TP53 (0.47) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10086509 | 0.84 | NPC1 (0.52) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10085464 | 0.84 | UGCG (0.51) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10113488 | 0.83 | NPC1 (0.46) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10085858 | 0.83 | TP53 (0.46) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10085778 | 0.81 | TP53 (0.44) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10085777 | 0.80 | TP53 (0.43) | NPC1PKMRAB9ATP53SMN1; SMN2 | |
| SCHEMBL10086375 | 0.80 | NPC1 (0.45) | NPC1PKMRAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110681-B2 | Compounds for the treatment of spinal muscular atrophy and other uses | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-02-07 | — | — | US | disclosed |