⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14690991 | 0.67 | — | — | |
| SCHEMBL1393717 | 0.62 | — | — | |
| SCHEMBL7332054 | 0.62 | — | — | |
| SCHEMBL15209531 | 0.62 | — | — | |
| SCHEMBL4949306 | 0.62 | — | — | |
| SCHEMBL3708870 | 0.60 | — | — | |
| SCHEMBL16870040 | 0.58 | — | — | |
| SCHEMBL18007265 | 0.58 | — | — | |
| SCHEMBL11937438 | 0.49 | — | — | |
| SCHEMBL8415482 | 0.47 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12012467-B2 | Small molecule DCN1 inhibitors and therapeutic methods using the same | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-06-18 | — | — | US | disclosed |
| EP-3609876-B1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2022-03-30 | — | — | EP | disclosed |
| US-20200109167-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-04-09 | — | — | US | disclosed |
| EP-3609876-A1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Regents of The University of Michigan (US) | 2020-02-19 | — | — | EP | disclosed |
| EP-3601245-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Regents of The University of Michigan (US) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018191199-A1 | COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20180289677-A1 | Covalent Small Molecule DCN1 Inhibitors and Therapeutic Methods Using the Same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2018-10-11 | — | — | US | disclosed |
| WO-2018183411-A1 | SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-10-04 | — | — | WO | disclosed |
| US-8188126-B2 | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors | PIERRE FABRE MEDICAMENT (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20110021589-A1 | IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2011-01-27 | — | — | US | disclosed |
| EP-1511735-B1 | IMIDAZOLE COMPOUNDS AND THEIR USE AS LIGANDS OF THE ALPHA-\" ADRENORECEPTORS | PF MEDICAMENT (FR) | 2010-06-23 | — | — | EP | disclosed |
| CN-100379728-C | Novel imidazole compounds, method for preparing same and use thereof as medicines | PF MEDICAMENT (FR) | 2008-04-09 | — | — | CN | disclosed |
| US-20070197793-A1 | Imidazolic compounds and use thereof as alpha-2 adrenergic receptors | PIERRE FABRE MEDICAMENT (FR) | 2007-08-23 | — | — | US | disclosed |
| US-7220866-B2 | Imidazolic compounds and use thereof as alpha-2-adrenergic receptors | PIERRE FABRE MEDICAMENT (FR) | 2007-05-22 | — | — | US | disclosed |
| US-20060041001-A1 | Novel imidazolic compounds, method for preparing same and use thereif as medicines | PIERRE FABRE MEDICAMENT (FR) | 2006-02-23 | — | — | US | disclosed |
| US-20050222241-A1 | Pyrrole derivative and process for producing the same | NIPPON SODA CO., LTD | 2005-10-06 | — | — | US | disclosed |
| CN-1653052-A | Novel imidazole compounds, method for preparing same and use thereof as medicines | PF MEDICAMENT (FR) | 2005-08-10 | — | — | CN | disclosed |
| EP-1557419-A1 | PYRROLE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | NIPPON SODA CO., LTD. (JP) | 2005-07-27 | — | — | EP | disclosed |
| EP-1511735-A1 | IMIDAZOLE COMPOUNDS AND THEIR USE AS LIGANDS OF THE ALPHA-\" ADRENORECEPTORS | PIERRE FABRE MEDICAMENT (FR) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003097611-A1 | NOVEL IMIDAZOLE COMPOUNDS, METHOD FOR PREPARING SAME AND USE THEREOF AS MEDICINES | PIERRE FABRE MEDICAMENT (FR) | 2003-11-27 | — | — | WO | disclosed |