Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 17/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | GAK | O14976 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600928 | 0.79 | RIPK2 (0.65) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL601925 | 0.78 | RIPK2 (0.64) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL601822 | 0.78 | RIPK2 (0.63) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL600481 | 0.78 | RIPK2 (0.63) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL600919 | 0.77 | RIPK2 (0.74) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL601819 | 0.77 | RIPK2 (1.00) | RIPK2KCNH2MAPK14GAKLCK | |
| Water SCHEMBL601248 | 0.76 | RIPK2 (0.98) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL602467 | 0.76 | RIPK2 (0.82) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL600402 | 0.75 | RIPK2 (0.62) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL599934 | 0.74 | RIPK2 (0.70) | RIPK2KCNH2MAPK14GAKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041024-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | ABL1, MAP3K20, MAP3K19 | RIPK2 480/4885KCNH2 824/4885MAPK14 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.