Drometrizole

Drometrizole

SCHEMBL1011957

CC(C)(c1ccccc1)c1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)c2ccccc2)c1.Cc1ccc(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.62
RAB9A P51151 7/20 0.62
LMNA P02545 1/20 0.62
POLB P06746 2/20 0.42
ALDH1A1 P00352 6/20 0.40
SMN1; SMN2 Q16637 4/20 0.40
CNR1 P21554 3/20 0.40
CNR2 P34972 3/20 0.40
KDM4E B2RXH2 4/20 0.39
MAPT P10636 4/20 0.38
HPGD P15428 3/20 0.38
TDP1 Q9NUW8 2/20 0.38
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
IGF2BP2 Q9Y6M1 1/20 0.33
THRB P10828 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
ESR1 P03372 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15083635 0.90 NPC1 (0.46) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL29354035 0.89 NPC1 (0.46) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL29903 0.89 NPC1 (0.46) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL8861272 0.86 NPC1 (0.58) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL5510301 0.84 NPC1 (0.41) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL1499910 0.83 NPC1 (0.45) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL6558920 0.83 NPC1 (0.45) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL30393631 0.83 NPC1 (0.45) NPC1RAB9ALMNAPOLBALDH1A1
Drometrizole SCHEMBL1937812 0.83 NPC1 (0.64) NPC1RAB9ALMNAPOLBALDH1A1
SCHEMBL10673685 0.82 NPC1 (0.66) NPC1RAB9ALMNAPOLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048955-B2 Thin, lightweight; melt stability, flame retardancy; resin, inorganic filler and acidic organic compound ASAHI KASEI CHEMICALS CORPORATION (JP) 2011-11-01 US disclosed
EP-1741752-B1 MOLDED AROMATIC POLYCARBONATE AND RESIN COMPOSITION ASAHI KASEI CHEMICALS CORP (JP) 2011-01-05 EP disclosed
EP-1642958-B1 Use of a lubricating oil composition in a watch and watch containing the same CITIZEN HOLDINGS CO LTD (JP) 2010-07-28 EP disclosed
US-20080063861-A1 Aromatic Polycarbonate Molded Article and Resin Composition ASAHI KASEI KABUSHIKI KAISHA (JP) 2008-03-13 US disclosed
EP-1741752-A1 MOLDED AROMATIC POLYCARBONATE AND RESIN COMPOSITION Asahi Kasei Chemicals Corporation (JP) 2007-01-10 EP disclosed
EP-1201734-B1 Use of a LUBRICATING OIL COMPOSITION in a watch AND WATCH CONTAINING THE SAME CITIZEN WATCH CO LTD (JP) 2006-06-14 EP disclosed
EP-1642958-A1 Lubricating oil composition and watch using the same Citizen Watch Co., Ltd. (JP) 2006-04-05 EP disclosed
EP-1632555-A1 Lubricating oil composition and watch using the same Citizen Watch Co., Ltd. (JP) 2006-03-08 EP disclosed
US-20030050197-A1 Lubricating oil composition and watch using the same CITIZEN WATCH CO., LTD. (JP) 2003-03-13 US disclosed
EP-1201734-A1 LUBRICATING OIL COMPOSITIONS AND WATCH CONTAINING THE SAME Citizen Watch Co. Ltd. (JP) 2002-05-02 EP disclosed