Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119829 | 0.91 | ESRRA (0.47) | SLC6A4ESRRACDK2CCNT1CCNA2 | |
| SCHEMBL10119834 | 0.86 | ESRRA (0.41) | ESRRAPRMT5WDR77KDM1A | |
| SCHEMBL8270041 | 0.84 | SLC6A4 (0.43) | SLC6A4ESRRACDK2CCNT1CCNA2 | |
| SCHEMBL8138142 | 0.84 | SLC6A4 (0.65) | SLC6A4ESRRAHDAC6HDAC3HDAC1 | |
| SCHEMBL10119878 | 0.83 | SLC6A4 (0.43) | SLC6A4ESRRACDK2CCNT1CCNA2 | |
| SCHEMBL8269988 | 0.82 | CDK2 (0.43) | SLC6A4CDK2CCNT1CCNA2GSK3A | |
| SCHEMBL10119828 | 0.80 | SLC6A4 (0.46) | SLC6A4ESRRACDK2HASPINPRMT5 | |
| SCHEMBL10119759 | 0.79 | PRMT5 (0.41) | ESRRAPRMT5WDR77KDM1AEP300 | |
| SCHEMBL10119682 | 0.76 | SLC6A4 (0.44) | SLC6A4ESRRACDK2PRMT5WDR77 | |
| SCHEMBL8270017 | 0.76 | SLC6A4 (0.49) | SLC6A4CDK2HASPINPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781639-B1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-25 | — | — | EP | disclosed |