⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877824 | 0.89 | — | — | |
| SCHEMBL12442960 | 0.89 | — | — | |
| SCHEMBL10448706 | 0.87 | — | — | |
| SCHEMBL7875657 | 0.84 | — | — | |
| SCHEMBL12589185 | 0.83 | SLC6A2 (0.35) | — | |
| SCHEMBL12283456 | 0.83 | — | — | |
| SCHEMBL15806844 | 0.81 | PRMT1 (0.32) | — | |
| SCHEMBL20083936 | 0.79 | — | — | |
| SCHEMBL13911598 | 0.79 | — | — | |
| SCHEMBL13864436 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017182495-A1 | INDAZOLE DERIVATIVES THAT DOWN-REGULATE THE ESTROGEN RECEPTOR AND POSSESS ANTI-CANCER ACTIVITY | ASTRAZENECA AB (SE) | 2017-10-26 | — | — | WO | disclosed |
| US-20170216283-A1 | COMPOUNDS AND USES | ASTRAZENECA AB (SE) | 2017-08-03 | — | — | US | disclosed |
| US-20170216283-A1 | COMPOUNDS AND USES | ASTRAZENECA AB (SE) | 2017-08-03 | — | — | US | disclosed |
| US-9657001-B2 | Compounds and uses | ASTRAZENECA AB (SE) | 2017-05-23 | — | — | US | disclosed |
| US-9657001-B2 | Compounds and uses | ASTRAZENECA AB (SE) | 2017-05-23 | — | — | US | disclosed |
| US-20160326143-A1 | COMPOUNDS AND USES | ASTRAZENECA AB (SE) | 2016-11-10 | — | — | US | disclosed |
| US-20160326143-A1 | COMPOUNDS AND USES | ASTRAZENECA AB (SE) | 2016-11-10 | — | — | US | disclosed |
| EP-2678329-B1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-11-18 | — | — | EP | disclosed |
| WO-2015037939-A1 | A NOVEL PHTALAZINONE DERIVATIVES AND MANUFACTURING PROCESS THEREOF | ILDONG PHARM CO., LTD. (KR) | 2015-03-19 | — | — | WO | disclosed |
| US-20140349994-A1 | Novel 2-Amino-4,5,6,8-Tetrahydropyrazolo[3,4-b]Thiazolo [4,5-d]Azepine Derivatives and Their Use as Allosteric Modulators of Metabotropic Glutamate Receptors | ADDEX PHARMA S.A. (CH) | 2014-11-27 | — | — | US | disclosed |
| US-20140023636-A1 | AMINOCARBOXYLIC ACID DERIVATIVE AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-01-23 | — | — | US | disclosed |
| US-8575134-B2 | Aminocarboxylic acid derivative and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2013-11-05 | — | — | US | disclosed |
| US-20120040975-A1 | BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |