Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.39 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12167835 | 1.00 | SLC6A2 (0.42) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL685065 | 0.87 | BRD4 (0.47) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL684422 | 0.87 | BRD4 (0.47) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL684738 | 0.87 | BRD4 (0.47) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL8919457 | 0.84 | CYP2C9 (0.44) | POLBCYP2C9CYP2C19MEN1CYP2D6 | |
| SCHEMBL680865 | 0.84 | POLB (0.42) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL679766 | 0.84 | POLB (0.42) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL680823 | 0.84 | POLB (0.42) | SLC6A2HTR2ASLC6A4HRH1HTR2B | |
| SCHEMBL12167826 | 0.83 | AOC3 (0.40) | AOC3 | |
| SCHEMBL22758202 | 0.81 | CYP2C9 (0.41) | POLBCYP2C9CYP2C19MEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087336-A1 | AUTOPHAGY INDUCER AND INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NEOPLASMS | GENENTECH, INC. (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011130654-A1 | FOX03A AS PREDICTIVE BIOMARKER FOR PI3K/AKT KINASE PATHWAY INHIBITOR EFFICACY | GENENTECH, INC. (US) | 2011-10-20 | — | — | WO | disclosed |