Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.68 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.64 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6359114 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6359530 | 0.81 | CHRNB4 (1.00) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6663087 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6359532 | 0.81 | CHRNB4 (1.00) | CHRNB4CHRNA3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6358950 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6359115 | 0.81 | CHRNB4 (0.68) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| Hydrochloric Acid SCHEMBL8320771 | 0.79 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL9221449 | 0.79 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7957918 | 0.79 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL9120762 | 0.79 | CHRNB4 (0.65) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2404923-A1 | 7-azabicyclo[2.2.1]heptane derivatives useful for promoting smoking cessation | RESEARCH TRIANGLE INSTITUTE (US) | 2012-01-11 | — | — | EP | disclosed |