Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.43 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14307867 | 0.92 | HRH3 (0.43) | HRH3RAPGEF3KMT2AKDM4EMEN1 | |
| SCHEMBL7657972 | 0.92 | HRH3 (0.42) | HRH3 | |
| SCHEMBL10107170 | 0.81 | HRH3 (0.39) | HRH3RAPGEF3 | |
| SCHEMBL7655220 | 0.71 | HRH3 (0.39) | HRH3 | |
| SCHEMBL7660195 | 0.70 | HRH3 (0.47) | HRH3RAPGEF3KMT2AKDM4EMEN1 | |
| SCHEMBL7664998 | 0.67 | HRH3 (0.50) | HRH3KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL7659427 | 0.65 | HRH3 (0.67) | HRH3 | |
| SCHEMBL7655188 | 0.61 | HRH3 (0.42) | HRH3 | |
| SCHEMBL13959144 | 0.60 | HRH3 (0.67) | HRH3KMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL4046381 | 0.58 | HDAC1 (0.56) | HRH3RAPGEF3KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858895-B1 | PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY | SCHERING CORP (US) | 2012-06-20 | — | — | EP | disclosed |