Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.68 |
| ▸ | RET | P07949 | 9/20 | 0.68 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.68 |
| ▸ | SRC | P12931 | 4/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.68 |
| ▸ | CSF1R | P07333 | 4/20 | 0.68 |
| ▸ | FLT3 | P36888 | 4/20 | 0.68 |
| ▸ | ABL1 | P00519 | 4/20 | 0.68 |
| ▸ | PLK4 | O00444 | 3/20 | 0.68 |
| ▸ | LCK | P06239 | 3/20 | 0.68 |
| ▸ | KIT | P10721 | 3/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.68 |
| ▸ | TYK2 | P29597 | 3/20 | 0.68 |
| ▸ | KDR | P35968 | 3/20 | 0.68 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.68 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10122894 | 0.85 | AURKA (0.69) | AURKARETAURKBSRCNTRK1 | |
| SCHEMBL10122896 | 0.82 | AURKA (0.69) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL10122872 | 0.81 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL29355178 | 0.81 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL15668060 | 0.81 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL10122873 | 0.81 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL15239834 | 0.80 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL29379147 | 0.80 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL29381911 | 0.80 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 | |
| Enmd-2076 SCHEMBL29389572 | 0.80 | AURKA (1.00) | AURKARETAURKBSRCNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114870-B2 | Method of treating disease states using substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-8114870-B2 | Method of treating disease states using substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2012-02-14 | — | — | US | disclosed |