Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 18/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.54 |
| ▸ | GAK | O14976 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600813 | 0.90 | RIPK2 (0.78) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL600965 | 0.85 | RIPK2 (0.65) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL12180660 | 0.80 | RIPK2 (0.56) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL600382 | 0.80 | RIPK2 (0.53) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL601819 | 0.78 | RIPK2 (1.00) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL12496334 | 0.77 | RIPK2 (0.79) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL602467 | 0.77 | RIPK2 (0.82) | RIPK2KCNH2MAPK14GAKLCK | |
| Water SCHEMBL601248 | 0.77 | RIPK2 (0.98) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL12503537 | 0.77 | RIPK2 (0.78) | RIPK2KCNH2MAPK14GAKLCK | |
| SCHEMBL10123709 | 0.76 | RIPK2 (0.54) | RIPK2KCNH2MAPK14GAKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021580-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | WO | disclosed |