Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 17/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.64 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL600919 | 0.86 | RIPK2 (0.74) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL10123969 | 0.79 | RIPK2 (0.78) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL601819 | 0.78 | RIPK2 (1.00) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL599934 | 0.78 | RIPK2 (0.70) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL602467 | 0.77 | RIPK2 (0.82) | RIPK2KCNH2RIPK3MAPK14GAK | |
| Water SCHEMBL601248 | 0.77 | RIPK2 (0.98) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL600965 | 0.74 | RIPK2 (0.65) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL601925 | 0.74 | RIPK2 (0.64) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL12496283 | 0.73 | RIPK2 (0.63) | RIPK2KCNH2RIPK3MAPK14GAK | |
| SCHEMBL601822 | 0.73 | RIPK2 (0.63) | RIPK2KCNH2RIPK3MAPK14GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021580-A1 | QUINOLYL AMINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | WO | disclosed |