Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
| ▸ | CCNK | O75909 | 4/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 5/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127819 | 0.81 | PRKCI (0.63) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL12347990 | 0.81 | PRKCI (0.56) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL1718082 | 0.80 | PRKCI (0.55) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL1719341 | 0.78 | PRKCI (0.63) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL1718593 | 0.78 | PRKCI (0.63) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL27893877 | 0.78 | PRKCI (0.52) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL4792616 | 0.78 | PRKCI (0.58) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL1717896 | 0.78 | PRKCI (0.58) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL12346290 | 0.77 | PRKCI (0.51) | PRKCIJAK2PRKACAJAK3PRKCQ | |
| SCHEMBL1718292 | 0.76 | JAK2 (0.72) | PRKCIJAK2PRKACAJAK3PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |