Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 12/20 | 0.40 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718163 | 0.73 | JAK1 (0.60) | HPGDSJAK1JAK2TYK2JAK3 | |
| SCHEMBL1717444 | 0.72 | JAK1 (0.60) | HPGDSJAK1JAK2TYK2AURKA | |
| SCHEMBL10125409 | 0.72 | JAK1 (0.60) | HPGDSJAK1JAK2TYK2AURKA | |
| SCHEMBL1724204 | 0.71 | CCNT1 (0.47) | HPGDSJAK1JAK2CDK7CDK9 | |
| SCHEMBL1726149 | 0.70 | JAK3 (0.51) | HPGDSJAK1JAK2TYK2AURKA | |
| SCHEMBL1724112 | 0.69 | JAK3 (0.57) | JAK1JAK2TYK2AURKACCNK | |
| SCHEMBL10125390 | 0.68 | AXL (0.40) | JAK1JAK2TYK2AURKACCNK | |
| SCHEMBL12346313 | 0.65 | JAK1 (0.40) | HPGDSJAK1JAK2TYK2AURKA | |
| SCHEMBL15203406 | 0.65 | JAK1 (0.60) | HPGDSJAK1JAK2AURKAJAK3 | |
| SCHEMBL14511036 | 0.65 | CCNK (0.47) | JAK1JAK2TYK2AURKACCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |