Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 12/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.39 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10124957 | 0.94 | AKT1 (0.55) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL10124986 | 0.90 | AKT1 (0.53) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL14494574 | 0.89 | AKT1 (0.46) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL14494582 | 0.88 | AKT1 (0.47) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL12346465 | 0.85 | AKT1 (0.57) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL10125511 | 0.83 | AKT1 (0.59) | AKT1NUDT1AKT2AKT3CIT | |
| SCHEMBL10124948 | 0.83 | AKT1 (0.53) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL14494538 | 0.83 | AKT1 (0.47) | AKT1IKBKBCHUKTLR9TLR8 | |
| SCHEMBL12346607 | 0.81 | AKT1 (0.47) | AKT1TLR9TLR8TLR7NUDT1 | |
| SCHEMBL10125099 | 0.81 | AKT1 (0.55) | AKT1CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881983-B1 | PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE | VERTEX PHARMA (US) | 2012-01-11 | — | — | EP | disclosed |