⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783331 | 0.81 | — | — | |
| SCHEMBL5781626 | 0.78 | — | — | |
| SCHEMBL5784548 | 0.73 | — | — | |
| SCHEMBL5783216 | 0.72 | OGA (0.30) | — | |
| SCHEMBL85820 | 0.72 | GRM5 (0.44) | — | |
| SCHEMBL468941 | 0.72 | — | — | |
| SCHEMBL19228219 | 0.71 | NPC1 (0.41) | — | |
| SCHEMBL14425145 | 0.70 | — | — | |
| SCHEMBL18000492 | 0.70 | — | — | |
| SCHEMBL20843934 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376478-B1 | PYRIDYLOXYINDOLES INHIBITORS OF VEGF-R2 AND USE THEREOF FOR TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-04-19 | — | — | EP | claimed |
| CN-107602497-B | Preparation method of 3-amino-5-alkylisoxazole | 浦拉司科技（上海）有限责任公司 | 2020-05-22 | — | — | CN | disclosed |
| US-10053430-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORP. (US) | 2018-08-21 | — | — | US | disclosed |
| EP-2268623-B9 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORP (US) | 2018-02-28 | — | — | EP | disclosed |
| US-9868763-B2 | Modulators of protease activated receptors | THE UNIVERSITY OF QUEENSLAND (AU) | 2018-01-16 | — | — | US | disclosed |
| US-9868763-B2 | Modulators of protease activated receptors | THE UNIVERSITY OF QUEENSLAND (AU) | 2018-01-16 | — | — | US | disclosed |
| US-20170298029-A1 | RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2017-10-19 | — | — | US | disclosed |
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |
| US-9730937-B2 | RAF kinase modulator compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2017-08-15 | — | — | US | disclosed |
| US-9701711-B2 | Modulators of protease activated receptors | THE UNIVERSITY OF QUEENSLAND (AU) | 2017-07-11 | — | — | US | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20080188556-A1 | Water-Soluble Prodrugs of Florfenicol and its Analogs | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2008-08-07 | — | — | US | disclosed |
| US-20080188556-A1 | Water-Soluble Prodrugs of Florfenicol and its Analogs | SCHERING-PLOUGH ANIMAL HEALTH CORPORATION | 2008-08-07 | — | — | US | disclosed |
| US-20080153906-A1 | Water-Soluble Phenicol Prodrugs in a Lipophilic Vehicle System | INTERVET INC. | 2008-06-26 | — | — | US | disclosed |
| US-20080153906-A1 | Water-Soluble Phenicol Prodrugs in a Lipophilic Vehicle System | INTERVET INC. | 2008-06-26 | — | — | US | disclosed |
| US-20080146640-A1 | Water-Soluble Prodrugs of Chloramphenicol, Thiamphenicol, and Analogs Thereof | SCHERING-PLOUGH LTD. (CH) | 2008-06-19 | — | — | US | disclosed |
| US-20080146640-A1 | Water-Soluble Prodrugs of Chloramphenicol, Thiamphenicol, and Analogs Thereof | SCHERING-PLOUGH LTD. (CH) | 2008-06-19 | — | — | US | disclosed |
| US-20070155799-A1 | CARBONATES OF FENICOL ANTIBIOTICS | INTERVET INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155799-A1 | CARBONATES OF FENICOL ANTIBIOTICS | INTERVET INC. | 2007-07-05 | — | — | US | disclosed |
| EP-0044185-A2 | Imidazolidinone derivatives | ELI LILLY AND COMPANY (US) | 1982-01-20 | — | — | EP | disclosed |