Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012725 | 1.00 | BRAF (0.76) | BRAFRAF1 | |
| SCHEMBL1012599 | 0.97 | BRAF (0.76) | BRAFRAF1 | |
| SCHEMBL17911693 | 0.89 | BRAF (0.89) | BRAFRAF1 | |
| SCHEMBL19258208 | 0.87 | BRAF (0.99) | BRAFRAF1 | |
| SCHEMBL1013737 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1011954 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1013022 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1012290 | 0.86 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1013251 | 0.86 | RAF1 (1.00) | BRAFRAF1 | |
| SCHEMBL1012063 | 0.86 | BRAF (1.00) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |