Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K20 | Q9NYL2 | 18/20 | 0.37 |
| ▸ | BRAF | P15056 | 12/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129946 | 0.94 | BRAF (0.42) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL10130214 | 0.88 | BRAF (0.38) | MAP3K20BRAF | |
| SCHEMBL16573195 | 0.87 | MAP3K20 (0.40) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL16573196 | 0.85 | BRAF (0.36) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL16573206 | 0.81 | BRAF (0.46) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL10130220 | 0.80 | MAP3K20 (0.49) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL16573189 | 0.79 | BRAF (0.43) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL10129779 | 0.79 | BRAF (0.46) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL10130222 | 0.77 | MAP3K20 (0.47) | MAP3K20BRAFLCKLIMK1LIMK2 | |
| SCHEMBL10129781 | 0.77 | BRAF (0.59) | MAP3K20BRAFLCKLIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085127-A1 | NEW TRIAZOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |