Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14424735 | 1.00 | NPY5R (0.53) | NPY5REPHX1SMN1; SMN2GLAKDM4E | |
| SCHEMBL13203775 | 0.87 | NPY5R (0.52) | NPY5RSMN1; SMN2GLAGAAHPGD | |
| SCHEMBL13222420 | 0.87 | NPY5R (0.52) | NPY5RSMN1; SMN2GLAGAAHPGD | |
| SCHEMBL10114034 | 0.84 | EPHX1 (0.46) | EPHX1SMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL10133717 | 0.84 | NPY5R (0.49) | NPY5RSMN1; SMN2KDM4ECCR8KMT2A | |
| SCHEMBL13203795 | 0.84 | NPY5R (0.49) | NPY5RSMN1; SMN2KDM4ECCR8KMT2A | |
| SCHEMBL10133376 | 0.82 | GLA (0.62) | NPY5RSMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL10114293 | 0.82 | GLA (0.62) | NPY5RSMN1; SMN2GLAKDM4EGAA | |
| SCHEMBL13204244 | 0.80 | CYP1A2 (0.56) | NPY5RSMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL10114641 | 0.80 | CYP1A2 (0.56) | NPY5RSMN1; SMN2KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115027-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2012-02-14 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2011-02-17 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-20100292500-A1 | NPY Y5 ANTAGONIST | KAWANISHI YASUYUKI | 2010-11-18 | — | — | US | disclosed |
| US-7265130-B2 | NPY Y5 antagonist | SHIONOGI & CO., LTD. (JP) | 2007-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292500-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | NPY5R 1/4885EPHX1 3910/4885SMN1; SMN2 2197/4885 |
| US-20110039802-A1 | NPY Y5 ANTAGONIST | NPY5R, NPY1R, NPY2R | NPY5R 1/4885EPHX1 3699/4885SMN1; SMN2 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.