Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 20/20 | 0.92 |
| ▸ | CSNK2A2 | P19784 | 17/20 | 0.92 |
| ▸ | CSNK2B | P67870 | 17/20 | 0.92 |
| ▸ | CSNK2A3 | Q8NEV1 | 5/20 | 0.92 |
| ▸ | PIM1 | P11309 | 3/20 | 0.92 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.92 |
| ▸ | CLK2 | P49760 | 2/20 | 0.92 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.92 |
| ▸ | GAK | O14976 | 1/20 | 0.92 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.92 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.92 |
| ▸ | ULK1 | O75385 | 1/20 | 0.92 |
| ▸ | STK10 | O94804 | 1/20 | 0.92 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.92 |
| ▸ | CDK1 | P06493 | 1/20 | 0.92 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.92 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.92 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.92 |
| ▸ | CDK2 | P24941 | 1/20 | 0.92 |
| ▸ | TYK2 | P29597 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30486993 | 1.00 | CSNK2A1 (0.92) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| Silmitasertib SCHEMBL29381056 | 0.96 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| Silmitasertib SCHEMBL629082 | 0.96 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| Silmitasertib SCHEMBL30193004 | 0.96 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| Silmitasertib SCHEMBL30917987 | 0.95 | CSNK2A1 (0.98) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| SCHEMBL10134707 | 0.89 | CSNK2A1 (0.91) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| SCHEMBL25247670 | 0.89 | CSNK2A1 (0.73) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| SCHEMBL30486966 | 0.89 | CSNK2A1 (0.73) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| SCHEMBL10134709 | 0.88 | CSNK2A1 (0.92) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 | |
| SCHEMBL10134643 | 0.88 | CSNK2A1 (1.00) | CSNK2A1CSNK2A2CSNK2BCSNK2A3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023126951-A1 | INHIBITORS OF AUTOPHAGY-RELATED PROTEIN-PROTEIN INTERACTIONS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2023-07-06 | — | — | WO | disclosed |
| WO-2023126951-A1 | INHIBITORS OF AUTOPHAGY-RELATED PROTEIN-PROTEIN INTERACTIONS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2023-07-06 | — | — | WO | disclosed |
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2009-09-24 | — | — | US | disclosed |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | SENHWA BIOSCIENCES, INC. (TW) | 2009-09-24 | — | — | US | disclosed |
| WO-2009108912-A1 | PROTEIN KINASE MODULATORS | CYLENE PHARMACEUTICALS, INC. (US) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208792-A1 | PROTEIN KINASE MODULATORS | PIM1, PIM2, PIM3 | CSNK2A1 680/4885CSNK2A2 810/4885CSNK2B 772/4885 |
| US-20090239859-A1 | PROTEIN KINASE MODULATORS | PIM1, PIM2, PIM3 | CSNK2A1 680/4885CSNK2A2 810/4885CSNK2B 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.