Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.63 |
| ▸ | TOP2A | P11388 | 3/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8785935 | 0.86 | CSNK2A1 (0.66) | CSNK2A1TOP2ACSNK2A2CSNK2BPOLB | |
| SCHEMBL10134791 | 0.86 | CSNK2A1 (0.47) | CSNK2A1TOP2ACSNK2A2CSNK2BTLR9 | |
| SCHEMBL10134876 | 0.81 | CSNK2A1 (0.54) | CSNK2A1TOP2ACSNK2A2CSNK2BNCF1 | |
| SCHEMBL10132891 | 0.81 | CSNK2A1 (0.66) | CSNK2A1TOP2ACSNK2A2CSNK2BFLT3 | |
| SCHEMBL2688023 | 0.81 | RAD52 (0.51) | CSNK2A1TOP2ATLR9NCF1POLB | |
| SCHEMBL2691596 | 0.80 | CSNK2A1 (0.45) | CSNK2A1TOP2ACSNK2A2CSNK2BTLR9 | |
| SCHEMBL4971024 | 0.77 | CSNK2A1 (1.00) | CSNK2A1TOP2ACSNK2A2CSNK2BTLR9 | |
| SCHEMBL10134952 | 0.75 | CSNK2A1 (0.58) | CSNK2A1TOP2ACSNK2A2CSNK2BPOLB | |
| SCHEMBL13056932 | 0.74 | KDM4E (0.48) | CSNK2A1TOP2ACSNK2A2CSNK2BNCF1 | |
| SCHEMBL10135169 | 0.74 | CSNK2A1 (0.59) | CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168651-B2 | Protein kinase modulators | CYLENE PHARMACEUTICALS, INC. (US) | 2012-05-01 | — | — | US | disclosed |