Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.76 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5092793 | 0.86 | PTK2 (1.00) | PTK2MAPK8MAPK10HTTL3MBTL1 | |
| SCHEMBL7056886 | 0.83 | PTK2 (0.70) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL5096597 | 0.80 | PTK2 (0.56) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL1680689 | 0.79 | PTK2 (0.73) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL11946878 | 0.78 | PTK2 (0.71) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL13270043 | 0.78 | PTK2 (0.71) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL23323409 | 0.76 | PTK2 (0.69) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL19494280 | 0.75 | PTK2 (0.68) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL4357584 | 0.75 | PTPN2 (0.74) | PTK2MAPK8MAPK10HTTMAPT | |
| SCHEMBL18080772 | 0.74 | PTK2 (0.66) | PTK2MAPK8MAPK10HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035251-A1 | THIOPHENE INHIBITORS OF IKK-B SERINE-THREONINE PROTEIN KINASE | CHROMA THERAPEUTICS LD. (GB) | 2012-02-09 | — | — | US | disclosed |
| US-20110046210-A1 | SUBSTITUTED THIOPENECARBOXAMIDES AS IKK-BETA SERINE-, THREONINE-PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2011-02-24 | — | — | US | disclosed |
| US-20110039920-A1 | INHIBITORS OF IKK-BETA SERINE-THERONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046210-A1 | SUBSTITUTED THIOPENECARBOXAMIDES AS IKK-BETA SERINE-, THREONINE-PROTEIN KINASE INHIBITORS | IKBKE, CSNK1A1, CSNK1E | PTK2 1455/4885MAPK8 692/4885MAPK10 691/4885 |
| US-20120035251-A1 | THIOPHENE INHIBITORS OF IKK-B SERINE-THREONINE PROTEIN KINASE | IKBKE, IKBKB, NFKBIA | PTK2 741/4885MAPK8 247/4885MAPK10 202/4885 |
| US-20110039920-A1 | INHIBITORS OF IKK-BETA SERINE-THERONINE PROTEIN KINASE | CSNK1E, PACSIN2, CHUK | PTK2 1182/4885MAPK8 2048/4885MAPK10 893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.