Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.72 |
| ▸ | ABL1 | P00519 | 10/20 | 0.61 |
| ▸ | BCR | P11274 | 10/20 | 0.61 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1012455 | 0.99 | TRPV1 (0.71) | TRPV1ABL1BCRTNNI3KMEN1 | |
| SCHEMBL1013045 | 0.86 | TRPV1 (0.72) | TRPV1ABL1BCRFAAH | |
| SCHEMBL1012994 | 0.86 | TRPV1 (0.72) | TRPV1ABL1BCRTP53FAAH | |
| SCHEMBL1012547 | 0.86 | TRPV1 (0.72) | TRPV1ABL1BCRFAAH | |
| SCHEMBL1014073 | 0.86 | TRPV1 (0.69) | TRPV1ABL1BCRMEN1USP2 | |
| Hydrochloric Acid SCHEMBL1011887 | 0.85 | TRPV1 (0.71) | TRPV1ABL1BCRTP53FAAH | |
| SCHEMBL13868105 | 0.84 | TRPV1 (1.00) | TRPV1ABL1BCRFAAH | |
| SCHEMBL14108293 | 0.84 | TRPV1 (0.69) | TRPV1ABL1BCRFAAH | |
| SCHEMBL5799067 | 0.82 | TRPV1 (0.63) | TRPV1ABL1BCRTNNI3KMEN1 | |
| SCHEMBL16894166 | 0.81 | ABL1 (0.61) | TRPV1ABL1BCRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542692-B1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN | AMGEN INC (US) | 2011-01-05 | — | — | EP | claimed |
| US-7524874-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7524874-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-04-28 | — | — | US | disclosed |
| US-7396831-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-07-08 | — | — | US | disclosed |
| US-7396831-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-07-08 | — | — | US | disclosed |