⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729166 | 0.70 | — | — | |
| SCHEMBL11904405 | 0.64 | — | — | |
| SCHEMBL140548 | 0.64 | — | — | |
| SCHEMBL1628862 | 0.64 | — | — | |
| SCHEMBL16176584 | 0.64 | PTPN1 (0.32) | — | |
| SCHEMBL16176240 | 0.64 | PTPN1 (0.32) | — | |
| SCHEMBL19168030 | 0.64 | — | — | |
| SCHEMBL1628866 | 0.64 | — | — | |
| SCHEMBL16176245 | 0.64 | PTPN1 (0.32) | — | |
| SCHEMBL17232123 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271759-B1 | HOST CELLS AND METHODS OF PRODUCING DISULFIDE BOND CONTAINING PROTEINS | DANISCO US INC (US) | 2015-12-02 | — | — | EP | disclosed |
| US-8852886-B2 | Host cells and methods of producing disulfide bond containing proteins | DANISCO US INC. (US) | 2014-10-07 | — | — | US | disclosed |
| US-20110236926-A1 | Host Cells and Methods Of Producing Disulfide Bond Containing Proteins | DANISCO US INC. | 2011-09-29 | — | — | US | disclosed |
| EP-2271759-A1 | HOST CELLS AND METHODS OF PRODUCING DISULFIDE BOND CONTAINING PROTEINS | Danisco US Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| US-7816117-B2 | Prokaryotic host cells for expressing proteins rich in disulfide bonds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-10-19 | — | — | US | disclosed |
| WO-2009118651-A1 | HOST CELLS AND METHODS OF PRODUCING DISULFIDE BOND CONTAINING PROTEINS | DUBOIS JEAN-YVES FRANCOIS (FR) | 2009-10-01 | — | — | WO | disclosed |
| EP-2027269-A2 | PROKARYOTIC HOST CELLS FOR EXPRESSING PROTEINS RICH IN DISULFIDE BONDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-02-25 | — | — | EP | disclosed |
| US-7410788-B2 | Compositions and methods for production of disulfide bond containing proteins in host cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-08-12 | — | — | US | disclosed |
| WO-2007127735-A2 | PROKARYOTIC HOST CELLS FOR EXPRESSING PROTEINS RICH IN DISULFIDE BONDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-11-08 | — | — | WO | disclosed |
| US-20070254334-A1 | Prokaryotic host cells for expressing proteins rich in disulfide bonds | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-11-01 | — | — | US | disclosed |
| US-20060030022-A1 | Compositions and methods for production of disulfide bond containing proteins in host cells | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-02-09 | — | — | US | disclosed |
| US-6872563-B1 | Compositions and methods for production of disulfide bond containing proteins in host cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-03-29 | — | — | US | disclosed |