Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13926196 | 0.94 | CYP2C8 (0.69) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL14802313 | 0.90 | CYP2C8 (0.65) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL10143268 | 0.90 | CYP2C8 (0.64) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL10143822 | 0.89 | CYP2C8 (0.63) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL12665480 | 0.88 | CYP2C8 (1.00) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL14802274 | 0.88 | CYP2C8 (0.61) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL12665493 | 0.86 | CYP2C8 (0.85) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL12665585 | 0.85 | CYP2C8 (0.89) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL14802276 | 0.85 | CYP2C8 (0.59) | CYP2C8KMT2AMEN1RCE1KDM4E | |
| SCHEMBL13906259 | 0.85 | CYP2C8 (0.79) | CYP2C8KMT2AMEN1RCE1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404845-B2 | 2,3-substituted azaindole derivatives for treating viral infections | MERCK SHARP & DOHME CORP. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404845-B2 | 2,3-substituted azaindole derivatives for treating viral infections | MERCK SHARP & DOHME CORP. (US) | 2013-03-26 | — | — | US | disclosed |
| EP-2195317-B1 | 2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORP (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2009032125-A1 | 2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |