SCHEMBL10143644

SCHEMBL10143644

Cc1ccc(C)c(Nc2cc(N3CCCCC3)nc(N3CCN(c4ncccc4C(F)(F)F)CC3)n2)c1

nearest known ligand 0.98

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GALR2 O43603 6/20 0.98
GALR1 P47211 4/20 0.98
TRPV1 Q8NER1 12/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10144203 0.99 GALR2 (1.00) GALR2GALR1TRPV1
SCHEMBL3243408 0.88 GALR2 (0.81) GALR2GALR1TRPV1
SCHEMBL3233075 0.88 GALR2 (0.81) GALR2GALR1TRPV1
SCHEMBL10144200 0.84 GALR2 (1.00) GALR2GALR1TRPV1
SCHEMBL5446545 0.83 GALR2 (0.79) GALR2GALR1TRPV1
SCHEMBL10143743 0.83 GALR2 (0.72) GALR2GALR1
SCHEMBL10144202 0.80 GALR2 (1.00) GALR2GALR1TRPV1
SCHEMBL5455407 0.80 GALR2 (0.68) GALR2GALR1TRPV1
SCHEMBL3236798 0.79 GALR2 (0.64) GALR2GALR1TRPV1
SCHEMBL10143643 0.78 GALR1 (0.98) GALR2GALR1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012009258-A2 PEPTIDOMIMETIC GALANIN RECEPTOR MODULATORS ROBERTS EDWARD (US) 2012-01-19 WO disclosed