Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.61 |
| ▸ | PLK3 | Q9H4B4 | 14/20 | 0.61 |
| ▸ | PLK2 | Q9NYY3 | 13/20 | 0.61 |
| ▸ | BRD4 | O60885 | 5/20 | 0.59 |
| ▸ | TAF1 | P21675 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.51 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | NEK4 | P51957 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.51 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.51 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.51 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.51 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376189 | 0.91 | PLK1 (0.64) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376190 | 0.91 | PLK1 (0.64) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376760 | 0.88 | PLK1 (0.60) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL376762 | 0.84 | PLK1 (0.61) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL13227772 | 0.82 | PLK1 (0.58) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3785572 | 0.80 | PLK1 (0.55) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3785568 | 0.80 | PLK1 (0.55) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3775720 | 0.80 | PLK1 (0.67) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL3775708 | 0.80 | PLK1 (0.67) | PLK1PLK3PLK2BRD4TAF1 | |
| SCHEMBL17507123 | 0.80 | BRD4 (0.79) | PLK1PLK3PLK2BRD4TAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |