SCHEMBL10143853

SCHEMBL10143853

O=C(O)c1c(-c2ccc[nH]c2=O)c2c(n1Cc1cc(F)ccc1F)=NCC(Cl)C=2

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP2C8 P10632 1/20 0.43
KMT2A Q03164 5/20 0.35
MEN1 O00255 2/20 0.32
SIGMAR1 Q99720 1/20 0.31
RORC P51449 1/20 0.31
RIPK1 Q13546 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10143359 0.82 FFAR4 (0.36) RORC
SCHEMBL12674114 0.75 CYP2C8 (0.40) CYP2C8KMT2A
SCHEMBL14802267 0.75 CYP2C8 (0.51) CYP2C8KMT2AMEN1RORC
SCHEMBL10078213 0.74 CYP2C8 (0.51) CYP2C8KMT2AMEN1RORCRIPK1
SCHEMBL12673666 0.73 CYP2C8 (0.39) CYP2C8KMT2A
SCHEMBL13395084 0.73 CYP2C8 (0.46) CYP2C8KMT2AMEN1RORCRIPK1
SCHEMBL12665086 0.73 CYP2C8 (0.55) CYP2C8KMT2AMEN1
SCHEMBL12665358 0.73 CYP2C8 (0.51) CYP2C8KMT2AMEN1
SCHEMBL13395063 0.73 CYP2C8 (0.44) CYP2C8KMT2AMEN1RORC
SCHEMBL13395078 0.73 CYP2C8 (0.45) CYP2C8KMT2AMEN1RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2195317-B1 2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS SCHERING CORP (US) 2012-01-18 EP disclosed
WO-2009032125-A1 2,3-SUBSTITUTED AZAINDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS SCHERING CORPORATION (US) 2009-03-12 WO disclosed