SCHEMBL10143955

SCHEMBL10143955

O=[N+]([O-])c1ccc(O)c(/C=N/c2cc(Cl)cc(Cl)c2)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.60
FNTB P49356 1/20 0.60
MAPT P10636 10/20 0.59
ALDH1A1 P00352 7/20 0.59
GAA P10253 4/20 0.59
SMN1; SMN2 Q16637 4/20 0.59
HPGD P15428 2/20 0.59
MAOB P27338 1/20 0.58
POLB P06746 4/20 0.57
ERN1 O75460 1/20 0.55
MEN1 O00255 6/20 0.54
KMT2A Q03164 6/20 0.54
NPC1 O15118 5/20 0.54
HTT P42858 3/20 0.54
RAB9A P51151 3/20 0.54
XBP1 P17861 1/20 0.54
KDM4E B2RXH2 3/20 0.53
LMNA P02545 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
AGTR1 P30556 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1950800 0.89 FNTA (0.67) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL1950799 0.89 FNTA (0.67) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL22624733 0.88 FNTA (0.60) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL22611887 0.83 FNTA (0.79) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL14011737 0.83 FNTA (0.79) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL22624833 0.83 FNTA (0.70) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL11814348 0.82 MAPT (0.57) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL11814353 0.82 MAPT (0.57) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL22624760 0.81 FNTA (0.67) FNTAFNTBMAPTALDH1A1GAA
SCHEMBL1949785 0.81 FNTA (0.67) FNTAFNTBMAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120100609-A1 N-LINKED GLYCAN BIOSYNTHESIS MODULATORS BIOMARIN PHARMACEUTICAL INC. 2012-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120100609-A1 N-LINKED GLYCAN BIOSYNTHESIS MODULATORS ENGASE, GALNT1, GALNT13 FNTA 55/4885FNTB 64/4885MAPT 2982/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.