Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | GABBR2 | O75899 | 7/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 7/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145905 | 1.00 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541903 | 1.00 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541084 | 1.00 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541730 | 1.00 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL12796694 | 0.95 | CXCR4 (0.39) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541902 | 0.93 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541731 | 0.93 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541729 | 0.93 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541904 | 0.93 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD | |
| SCHEMBL541083 | 0.93 | KDR (0.41) | KDRAURKBHRH4CXCR4SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415765-A1 | PYRIMIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2012-02-08 | — | — | EP | disclosed |