Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PARG | Q86W56 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992331 | 0.85 | GRM2 (0.40) | GRM2PARGBRD4CTSDGRIN1 | |
| SCHEMBL10146576 | 0.81 | GRM2 (0.64) | GRM2PARGBRD4GRIN1GRIN2B | |
| SCHEMBL626500 | 0.80 | MAPK14 (0.52) | GRM2PARGCRHR1CRHR2OPRM1 | |
| SCHEMBL627781 | 0.79 | ADORA2A (0.40) | GRM2PARGICMTCNR1CNR2 | |
| SCHEMBL627103 | 0.78 | GRM2 (0.47) | GRM2PARGBRD4PDE5APDE4A | |
| SCHEMBL10145991 | 0.78 | PARG (0.57) | GRM2PARGGRIN1GRIN2BMETAP2 | |
| SCHEMBL625470 | 0.77 | BRD4 (0.47) | GRM2BRD4PDE5APDE4APDE4B | |
| SCHEMBL627531 | 0.76 | GRM2 (0.41) | GRM2PARGGRIN1GRIN2BICMT | |
| SCHEMBL626547 | 0.75 | PARG (0.45) | GRM2PARGMETAP2OPRM1 | |
| SCHEMBL625527 | 0.71 | GRM2 (0.51) | GRM2PARGGRIN1GRIN2BICMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |