Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 18/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10146402 | 0.86 | GRM2 (0.41) | GRM2PTAFRHTR2B | |
| SCHEMBL10146651 | 0.85 | GRM2 (0.50) | GRM2PTAFRHTR2B | |
| SCHEMBL625581 | 0.80 | GRM2 (0.47) | GRM2 | |
| SCHEMBL10146414 | 0.79 | GRM2 (0.42) | GRM2PTAFRHTR2B | |
| SCHEMBL10146684 | 0.77 | GRM2 (0.44) | GRM2 | |
| SCHEMBL10146393 | 0.76 | GRM2 (0.41) | GRM2 | |
| SCHEMBL10146394 | 0.76 | GRM2 (0.45) | GRM2 | |
| SCHEMBL10146415 | 0.75 | GRM2 (0.44) | GRM2PTAFRHTR2B | |
| SCHEMBL626425 | 0.71 | GRM2 (0.47) | GRM2 | |
| SCHEMBL14992567 | 0.71 | GRM2 (0.45) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |